abstract：:We studied the effects of two antiviral agents, human interferon-alpha (IFN-alpha) and ribavirin, on subacute sclerosing panencephalitis (SSPE) virus infections in hamsters. By intracranial administration, IFN-alpha alone improved the survival of infected hamsters by 20% at a dose of 6 x 10(4) IU/kg every other day fo...

journal_title：Antiviral research

authors： Takahashi T,Hosoya M,Kimura K,Ohno K,Mori S,Takahashi K,Shigeta S

更新日期：1998-01-01 00:00:00

abstract：:PMEA [9-[2-(phosphonomethoxy)ethyl]adenine; adefovir] has shown anti-cytomegalovirus activity in animal models and in preliminary human trials. PMEA diphosphate (PMEApp), the active antiviral metabolite of PMEA, is a potent inhibitor of human cytomegalovirus (HCMV) DNA polymerase. PMEA is efficiently taken up and phos...

journal_title：Antiviral research

authors： Xiong X,Flores C,Fuller MD,Mendel DB,Mulato AS,Moon K,Chen MS,Cherrington JM

更新日期：1997-11-01 00:00:00

abstract：:The identification of more effective and less toxic foscarnet (PFA) analogs for antiviral therapy would be useful. We recently synthesized 1-O-octadecyl-sn-glycero-3-phosphonoformic acid (ODG-PFA) and noted a 93-fold increase in its anti-HCMV activity relative to PFA. In addition, the antiviral activity of ODG-PFA in ...

journal_title：Antiviral research

authors： Kini GD,Beadle JR,Xie H,Aldern KA,Richman DD,Hostetler KY

更新日期：1997-09-01 00:00:00

abstract：:Forty-nine subjects were enrolled in a study comparing two dosages of parenterally administered interferon (IFN)-beta in combination with cryotherapy for the treatment of anogenital warts. Subjects were randomized to receive subcutaneous injections of either 2 x 10(6) or 4 x 10(6) IU/m2 of IFN-beta (Biogen) three time...

journal_title：Antiviral research

authors： Bonnez W,Oakes D,Bailey-Farchione A,Choi A,Hallahan D,Corey L,Barnum G,Pappas PG,Halloway M,Stoler MH,Reichman RC

更新日期：1997-06-01 00:00:00

abstract：:Carbovir (CBV) is a guanine nucleoside analog with potent in vitro anti-HIV activity. A prodrug of CBV is currently being evaluated in clinical trials as a potential agent for the treatment of AIDS. The ability of CBV to inhibit mitochondrial DNA synthesis in intact CEM cells was evaluated in the present study, becaus...

journal_title：Antiviral research

authors： Parker WB,Shaddix SC,Vince R,Bennett LL Jr

更新日期：1997-05-01 00:00:00

abstract：:Prostratin, a non-tumor-promoting phorbol ester, inhibited human immunodeficiency virus (HIV)-induced cell killing and viral replication in a variety of acutely-infected cell systems. The potency and degree of cytoprotection was dependent on both viral strain and host cell type. Prostratin activated viral expression i...

journal_title：Antiviral research

authors： Gulakowski RJ,McMahon JB,Buckheit RW Jr,Gustafson KR,Boyd MR

更新日期：1997-01-01 00:00:00

abstract：:The bovine immunodeficiency virus (BIV) and human immunodeficiency virus types 1 and 2 (HIV-1 and -2) are members of the lentivirus genus of retroviruses. Although DNA sequences of these viruses have diverged considerably, the BIV genome organization, function of structural and regulatory genes, and replication cycle ...

journal_title：Antiviral research

authors： Tobin GJ,Ennis WH,Clanton DJ,Gonda MA

更新日期：1996-12-01 00:00:00

abstract：:Novel L-lyxo-TSAO-T analogs with an inverted configuration at the C-4'-position of the sugar moiety and 5'-deoxy-5'-modified TSAO-T derivatives have been prepared and evaluated for their inhibitory effect on human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) replication in cell culture. None of the compoun...

journal_title：Antiviral research

authors： Ingate S,De Clercq E,Balzarini J,Camarasa MJ

更新日期：1996-11-01 00:00:00

abstract：:The model of simian immunodeficiency virus (SIV) infection in rhesus macaques was used to evaluate the effects of recombinant human interferon alpha, Hu IFN-alpha 2b and Hu IFN-gamma B,D, at two doses. Administration began 1 day prior to infection and was continued for 90 days postinfection. Both interferons suppresse...

journal_title：Antiviral research

authors： Schellekens H,Niphuis H,Buijs L,Douw van der Krap P,Hochkeppel HK,Heeney JL

更新日期：1996-08-01 00:00:00

abstract：:We established a sensitive and accurate method for screening of anti-adenovirus agents using the 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. MKN-28 cells, which are well-differentiated stomach adenocarcinoma cells, were used for adenovirus (ADV) infection and examined for the anti-ADV act...

journal_title：Antiviral research

authors： Kodama E,Shigeta S,Suzuki T,De Clercq E

更新日期：1996-07-01 00:00:00

abstract：:We have investigated viral breakthrough during a long-term culture of HIV-1-infected cells with the non-nucleoside reverse transcriptase inhibitors (NNRTIs) 6-benzyl-1-ethoxymethyl-5-isopropyluracil (MKC-442), nevirapine and loviride (alpha-APA). When the compounds were examined for their inhibitory effects on HIV-1 (...

journal_title：Antiviral research

authors： Okamoto M,Makino M,Yamada K,Nakade K,Yuasa S,Baba M

更新日期：1996-06-01 00:00:00

abstract：:An extract of the cactus plant Opuntia streptacantha inhibited intracellular virus replication and inactivated extracellular virus. Inhibition of virus replication also occurred following pre-infection treatment--a favourable finding in terms of in-vivo limitation of virus disease. There was inhibition of both DNA and...

journal_title：Antiviral research

authors： Ahmad A,Davies J,Randall S,Skinner GR

更新日期：1996-05-01 00:00:00

abstract：:The bicyclams represent a new class of highly potent and selective HIV inhibitors. Time-of-addition experiments have previously shown that these compounds interfere with an early event in the viral replicative cycle. Additional experiments have now been carried out in order to investigate in more detail the mechanism ...

journal_title：Antiviral research

authors： De Vreese K,Reymen D,Griffin P,Steinkasserer A,Werner G,Bridger GJ,Esté J,James W,Henson GW,Desmyter J,Anné J,De Clercq I

更新日期：1996-03-01 00:00:00

abstract：:The Cytomegalovirus Retinitis Retreatment Trial was a multicenter clinical trial designed to evaluate three treatments for the treatment of relapsed CMV retinitis; (1) foscarnet; (2) 'high-dose' ganciclovir, and (3) combination foscarnet and ganciclovir. Two hundred seventy-nine patients were enrolled and randomly ass...

journal_title：Antiviral research

authors： Jabs DA

更新日期：1996-01-01 00:00:00

abstract：:The first 230 residues of the 298-amino acid glycoprotein G of respiratory syncytial virus (RSV) are sufficient to confer complete resistance to challenge with live RSV, whereas the first 180 residues completely failed (Olmsted et al. (1989) J. Virol. 63, 411-420). The characterization of a protective epitope correspo...

journal_title：Antiviral research

authors： Simard C,Nadon F,Séguin C,Trudel M

更新日期：1995-12-01 00:00:00

abstract：:Preventive intraperitoneal trehalose dimycolate (TDM) treatment of mice, inoculated with encephalomyocarditis (EMC) virus by the same route, caused restriction of virus growth in the peritoneum, which was correlated to IFN production in peritoneal fluids prior to infection. Peritoneal macrophages from TDM-treated mice...

journal_title：Antiviral research

authors： Guillemard E,Geniteau-Legendre M,Kergot R,Lemaire G,Petit JF,Labarre C,Quero AM

更新日期：1995-10-01 00:00:00

abstract：:We studied susceptibility to herpes labialis by exposing 20 volunteers to experimental ultraviolet radiation (UVR) on three occasions at 3- to 4-month intervals. The number of patients who developed lesions after each session was 9/20 (45%), 9/20 (45%) and 14/20 (70%). Herpes simplex virus (HSV) was isolated from 21/2...

journal_title：Antiviral research

authors： Spruance SL,Kriesel JD,Evans TG,McKeough MB

更新日期：1995-09-01 00:00:00

abstract：:While the combination of zidovudine and didanosine is used in HIV-infected patients with more advanced disease, the possibility of a pharmacokinetic interaction between these two drugs remains controversial. Zidovudine doses of 50, 100, and 200 mg, combined with 67, 167, and 250 mg of didanosine were evaluated in 11 a...

journal_title：Antiviral research

authors： Morse GD,Shelton MJ,Ho M,Bartos L,DeRemer M,Ragni M

更新日期：1995-08-01 00:00:00

abstract：:Novel analogues of the anti-HIV-1 agent TSAO-T, [1-[2',5'-bis-O-(tert- butyldimethylsilyl)-beta-D-ribofuranosyl]thymine]-3'-spiro-5"-(4"-amino- 1",2"-oxathiole-2",2"-dioxide) and its 3-methyl counterpart TSAO-m3T were obtained by modifications at positions 2' or 5' of the sugar moiety. These compounds were evaluated f...

journal_title：Antiviral research

authors： Ingate S,Pérez-Pérez MJ,De Clercq E,Balzarini J,Camarasa MJ

更新日期：1995-06-01 00:00:00

abstract：:Synthetic flavans, isoflavans and isoflavenes substituted with chloro, cyano and amidino groups were tested for their in vitro activity against poliovirus type 2, Coxsackie virus B4, echovirus type 6 and enterovirus 71. Plaque-reduction assays showed that substituted 3-(2H)-isoflavenes, carrying a double bond in the o...

journal_title：Antiviral research

authors： Genovese D,Conti C,Tomao P,Desideri N,Stein ML,Catone S,Fiore L

更新日期：1995-05-01 00:00:00

abstract：:The antiviral effect of foscarnet (PFA) on the replication of rotavirus, a member of the Reoviridae, was studied. The pyrophosphate analogue is an effective inhibitor of several viral polymerases acting on the enzyme pyrophosphate binding site. Replication of rotavirus in MA104 cells using different u.o.i. was inhibit...

journal_title：Antiviral research

authors： Ríos M,Muñoz M,Spencer E

更新日期：1995-05-01 00:00:00

abstract：:Prostaglandins are potentially useful antiviral agents, however their mechanism of action is unclear. Recent evidence suggests that RNA transcription of vesicular stomatitis virus (VSV) is inhibited by prostaglandins (Bader and Ankel, J. Gen. Virol. 71, 2823-2832, 1990). Prostaglandins are known to have multiple effec...

journal_title：Antiviral research

authors： Parker J,Ahrens PB,Ankel H

更新日期：1995-01-01 00:00:00

abstract：:Oligodeoxynucleotides (ODNs) composed entirely of deoxyguanosine and thymidine, but not specifically designed to act as antisense agents, were able to significantly inhibit herpes simplex virus growth in acute infection assay systems. The guanosine/thymidine (GT) ODNs which demonstrated this antiviral activity contain...

journal_title：Antiviral research

authors： Fennewald SM,Mustain S,Ojwang J,Rando RF

更新日期：1995-01-01 00:00:00

abstract：:Derivation of the 2-aminobenzylstatine containing HIV-1 proteinase (PR) inhibitor I led to a series of compounds with considerably improved antiviral activity, the most potent derivatives inhibiting HIV-1 with IC50 values below 25 nM. This was achieved by the combination of several structural modifications, most promi...

journal_title：Antiviral research

authors： Billich A,Charpiot B,Fricker G,Gstach H,Lehr P,Peichl P,Scholz D,Rosenwirth B

更新日期：1994-12-01 00:00:00

abstract：:Previous studies of IFN-stimulated transcription factors in murine cells have identified a variety of trans-acting factors that bind to the IFN-stimulated response element (ISRE) whose role in gene expression remain unclear. The present investigation was undertaken to delineate the signal transduction pathway as well ...

journal_title：Antiviral research

authors： Kalvakolanu DV,Mannino SB,Thornton A,Ozato K,Borden EC

更新日期：1994-10-01 00:00:00

abstract：:Desferrioxamine (DFO) is commonly used in therapy as a chelator of ferric ion in disorders of iron overload. We found that DFO inhibits human cytomegalovirus (HCMV) replication in infected cultures of human foreskin fibroblasts (HFF) at concentrations that have been achieved in humans with no significant adverse effec...

journal_title：Antiviral research

authors： Cinatl J Jr,Cinatl J,Rabenau H,Gümbel HO,Kornhuber B,Doerr HW

更新日期：1994-09-01 00:00:00

abstract：:Preclinical evaluation of the effectiveness of interferon (IFN) therapy on human papillomaviruses (HPV) has been hampered by the inability to propagate these viruses in cell culture. Nonetheless, interferon is used extensively in the treatment of HPV infections. Alpha interferons in particular have found a place in th...

journal_title：Antiviral research

authors： Gangemi JD,Pirisi L,Angell M,Kreider JW

更新日期：1994-07-01 00:00:00

abstract：:Human CMV causes a number of diseases that cause considerable morbidity and that can be life-threatening in immunocompromised patients, particularly those with AIDS. Ganciclovir (GCV) and Foscarnet (PFA) are currently the drugs of choice for management of CMV disease. Both are not without side effects and have a relat...

journal_title：Antiviral research

authors： Nokta M,Tolpin MD,Nadler PI,Pollard RB

更新日期：1994-05-01 00:00:00

abstract：:The creatine kinase/creatine phosphate (CK/CrP) system plays an important role in cellular energy homeostasis. CK isoenzymes, which reversibly generate ATP from CrP, are compartmentalized at cellular sites where energy is produced or utilized. It has been noted that the expression of CK is induced in cells infected by...

journal_title：Antiviral research

authors： Lillie JW,Smee DF,Huffman JH,Hansen LJ,Sidwell RW,Kaddurah-Daouk R

更新日期：1994-04-01 00:00:00

abstract：:Cell-to-cell contact is usually essential for syncytium formation by HTLV-I-infected cell lines. The present study was undertaken to determine the inhibitory effect of polyanionic compounds, dextran sulfate and heparin, on HTLV-I-induced syncytium formation, as demonstrated by the fusion of HTLV-I-infected cells with ...

journal_title：Antiviral research

authors： Ida H,Kurata A,Eguchi K,Yamashita I,Nakashima M,Sakai M,Kawabe Y,Nakamura T,Nagataki S

更新日期：1994-02-01 00:00:00

abstract：:The therapeutic efficacy of aerosolized aprotinin, a natural proteinase inhibitor, against influenza and paramyxovirus bronchopneumonia of mice is shown. Small-particle aerosol of aprotinin solution was generated by a Collison type nebulizer and infected mice were exposed to aerosol atmosphere by four 30-40 min incuba...

journal_title：Antiviral research

authors： Ovcharenko AV,Zhirnov OP

更新日期：1994-02-01 00:00:00

abstract：:Argentine hemorrhagic fever is a systemic viral disease caused by Junin virus, with a mortality of 15-30% in untreated individuals. Current specific therapy is highly effective in reducing mortality, and consists of the early administration of immune plasma in defined doses of specific neutralizing antibodies per kg o...

journal_title：Antiviral research

authors： Enria DA,Maiztegui JI

更新日期：1994-01-01 00:00:00

abstract：:On the basis of three different models (namely: ddU, AZT and PMEA), mononucleotide phosphotriester derivatives were designed to be able to liberate the corresponding monophosphate (or phosphonate) inside the cell through a reductase-mediated activation process. It was demonstrated that the use of bis[S-(2-hydroxyethyl...

journal_title：Antiviral research

authors： Puech F,Gosselin G,Lefebvre I,Pompon A,Aubertin AM,Kirn A,Imbach JL

更新日期：1993-10-01 00:00:00

abstract：:A novel substituted naphthalenone (TGG-II-23A) has been found that inhibits HIV-1 infection of CEM-SS cells at concentrations that are not cytotoxic. Time of addition experiments indicate that TGG-II-23A functions at a stage of the HIV-1 life cycle at or near reverse transcription. Cell free assays confirmed that TGG-...

journal_title：Antiviral research

authors： Alam M,Bechtold CM,Patick AK,Skoog MT,Gant TG,Colonno RJ,Meyers AI,Li H,Trimble J,Lin PF

更新日期：1993-10-01 00:00:00

abstract：:The antiviral activity of antisense oligonucleotides corresponding to different regions of foot-and-mouth disease virus (FMDV) genome has been assessed in BHK-21 cells. The locations of the oligonucleotides used were: (i) two regions within the internal ribosome entry site (IRES), involved in the regulation of the tra...

journal_title：Antiviral research

authors： Gutiérrez A,Rodríguez A,Pintado B,Sobrino F

更新日期：1993-09-01 00:00:00

abstract：:Knowledge of drug protein-binding and blood cell partitioning may be important for evaluating the pharmacokinetic parameters of zidovudine, particularly because of its intracellular site of action and potential to induce side effects. Equilibrium dialysis studies of zidovudine were performed over 2 h to identify the e...

journal_title：Antiviral research

authors： Luzier A,Morse GD

更新日期：1993-07-01 00:00:00

abstract：:The ability of hypericin to protect mice from splenomegaly resulting from infection with Friend leukemia virus (FLV) was re-examined in light of recent evidence showing that light is absolutely required for this drug's antiviral activity. FLV-induced splenomegaly was not prevented or ameliorated in mice injected with ...

journal_title：Antiviral research

authors： Stevenson NR,Lenard J

更新日期：1993-06-01 00:00:00

abstract：:Ampligen, a known immunomodulator and interferon inducer, was used alone and in combination with other antiviral agents to treat ducks congenitally-infected with duck hepatitis B virus. These antiviral agents included the conventional nucleoside analogue ganciclovir and the prokaryotic DNA gyrase B inhibitor coumermyc...

journal_title：Antiviral research

authors： Niu J,Wang Y,Dixon R,Bowden S,Qiao M,Einck L,Locarnini S

更新日期：1993-06-01 00:00:00

abstract：:Sulfated derivatives of paramylon, a water-insoluble (1-3)-beta-D-glucan from Euglena gracilis, significantly inhibited the cytopathic effect of human immunodeficiency virus (HIV-1, HIV-2) and the expression of HIV antigen in cultured MT-4, MOLT-4 cells and human peripheral blood mononuclear cells. Native paramylon, N...

journal_title：Antiviral research

authors： Koizumi N,Sakagami H,Utsumi A,Fujinaga S,Takeda M,Asano K,Sugawara I,Ichikawa S,Kondo H,Mori S

更新日期：1993-05-01 00:00:00

abstract：:A screening for inhibitors of human immunodeficiency virus type 1 (HIV-1) among various types of isopolyoxomolybdates and heteropolyoxomolybdates was carried out by using an in vitro assay system measuring the cytopathogenicity of HIV-1 in CD4+ human MT-4 cells. A novel heteropolyoxomolybdate named PM-104 with the che...

journal_title：Antiviral research

authors： Inouye Y,Tokutake Y,Yoshida T,Seto Y,Hujita H,Dan K,Yamamoto A,Nishiya S,Yamase T,Nakamura S

更新日期：1993-04-01 00:00:00